SCHEMBL1594831

SCHEMBL1594831

NC(Cc1c[nH]c2c(Br)cccc12)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.62
KMT2A Q03164 3/20 0.62
KDM4E B2RXH2 3/20 0.62
LMNA P02545 2/20 0.62
TSHR P16473 2/20 0.62
BLM P54132 2/20 0.62
PMP22 Q01453 2/20 0.62
MEN1 O00255 2/20 0.62
MPO P05164 1/20 0.62
HIF1A Q16665 1/20 0.62
TNF P01375 1/20 0.57
ALDH1A1 P00352 2/20 0.51
CYP3A4 P08684 1/20 0.51
HTR1A P08908 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
ALOX15 P16050 1/20 0.51
NFKB1 P19838 1/20 0.51
HTR2A P28223 1/20 0.51
HTR2C P28335 1/20 0.51
SLC6A4 P31645 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18029211 1.00 MAPT (0.62) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL1594834 1.00 MAPT (0.62) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL28419283 0.89 KMT2A (0.59) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL28419284 0.89 KMT2A (0.59) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL19846987 0.88 SOS2 (0.48) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL1460650 0.86 MAPT (0.69) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL18029110 0.86 MAPT (0.69) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL1460647 0.86 MAPT (0.69) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL18029204 0.84 MAPT (0.63) MAPTKMT2AKDM4ELMNATSHR
SCHEMBL20816072 0.84 MAPT (0.63) MAPTKMT2AKDM4ELMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 289 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200247858-A1 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF FOG PHARMACEUTICALS, INC. (US) 2020-08-06 US claimed
EP-3678683-A2 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF Fog Pharmaceuticals, Inc. (US) 2020-07-15 EP claimed
CN-111372942-A β -catenin function modulating agents and methods thereof 弗格制药有限公司 2020-07-03 CN claimed
CN-111118048-A Use of chimeric phenylalanyl-tRNA synthetases/tRNAs 浙江大学 2020-05-08 CN claimed
WO-2019051327-A2 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF FOG PHARMACEUTICALS, INC. (US) 2019-03-14 WO claimed
US-5658885-A OLIGOPEPTIDES; ANTICOAGULANTS; ENZYME INHIBITORS; THROMBIN THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-19 US claimed
US-20260071243-A1 BIOLOGICAL PRODUCTION OF TRYPTOPHAN-DERIVED PRODUCTS UNIV TEXAS (US) 2026-03-12 US disclosed
US-20260002147-A1 ENGINEERED SYNTHASE FOR PRODUCTION OF TRYPTOPHAN DERIVATIVES AND INTRANSIGENT SUBSTRATES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2026-01-01 US disclosed
US-20250367300-A1 Nanomaterial and Methods of Use Thereof UNIVERSITY OF CONNECTICUT (US) 2025-12-04 US disclosed
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS UNIV DANMARKS TEKNISKE (DK) 2025-11-20 US disclosed
US-20250320253-A1 TRANSMEMBRANE PEPTIDIC ANTAGONISTS OF PLEXIN-A1 AND THEIR THERAPEUTIC USES UNIV STRASBOURG (FR) 2025-10-16 US disclosed
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF UNIVERSITY OF CONNECTICUT (US) 2025-10-02 US disclosed
US-12385029-B2 Engineered synthase for production of tryptophan derivatives and intransigent substrates CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2025-08-12 US disclosed
WO-2001064678-A2 INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-09-07 WO disclosed
WO-2001040262-A1 ALPHA-KETOAMIDE INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-06-07 WO disclosed
WO-2001002424-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE DU PONT PHARMACEUTICALS COMPANY (US) 2001-01-11 WO disclosed
WO-2000068413-A1 HALO- OR HYDROXY-SUBSTITUTED NOCATHIACIN ANTIBIOTICS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-11-16 WO disclosed
US-5658885-A OLIGOPEPTIDES; ANTICOAGULANTS; ENZYME INHIBITORS; THROMBIN THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-19 US disclosed
EP-0787010-A1 AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-06 EP disclosed
WO-1996012499-A1 AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-05-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250367300-A1 Nanomaterial and Methods of Use Thereof EPCAM, CD47, JAK2 MAPT 1013/4885KMT2A 718/4885KDM4E 848/4885
US-20200247858-A1 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF CTNNB1, CTNNBL1, CTNNA1 MAPT 3674/4885KMT2A 3036/4885KDM4E 1902/4885
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF JAK2, JAK1, CHMP4B MAPT 605/4885KMT2A 1471/4885KDM4E 2142/4885
US-12385029-B2 Engineered synthase for production of tryptophan derivatives and intransigent substrates WARS1, TPH1, TPH2 MAPT 2121/4885KMT2A 1560/4885KDM4E 2269/4885
US-20260071243-A1 BIOLOGICAL PRODUCTION OF TRYPTOPHAN-DERIVED PRODUCTS TPH1, TPH2, SLC6A4 MAPT 1647/4885KMT2A 1283/4885KDM4E 3485/4885
US-20260002147-A1 ENGINEERED SYNTHASE FOR PRODUCTION OF TRYPTOPHAN DERIVATIVES AND INTRANSIGENT SUBSTRATES INMT, TPH1, TPH2 MAPT 1835/4885KMT2A 1052/4885KDM4E 1227/4885
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS INMT, KARS1, MIA3 MAPT 3008/4885KMT2A 445/4885KDM4E 2243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.