Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.67 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.67 |
| ▸ | HTR2C | P28335 | 2/20 | 0.67 |
| ▸ | DRD1 | P21728 | 12/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1597249 | 0.99 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL1596293 | 0.94 | ADRA2A (0.63) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| Hydrochloric Acid SCHEMBL1596390 | 0.93 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL1893559 | 0.92 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| Bromide SCHEMBL1597617 | 0.92 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL1597645 | 0.91 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL1597473 | 0.91 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL1598502 | 0.91 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL5500470 | 0.91 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 | |
| SCHEMBL1596097 | 0.91 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CHTR2CSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919508-B2 | 3-piperidinylisochroman-5-ols as dopamine agonists | AVENTIS PHARMACEUTICALS INC. (US) | 2011-04-05 | — | — | US | disclosed |
| EP-1749001-B1 | 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS | AVENTIS PHARMA INC (US) | 2010-03-03 | — | — | EP | disclosed |
| US-20070099955-A1 | 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099955-A1 | 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS | DRD3, DRD2, DRD4 | ADRA2A 31/4885ADRA2B 43/4885ADRA2C 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.