Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 14/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967281 | 0.92 | SLC6A9 (0.59) | SLC6A9KCNH2SLC6A5PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL15967136 | 0.91 | SLC6A9 (0.59) | SLC6A9KCNH2SLC6A5PSEN1PSEN2 | |
| SCHEMBL15967219 | 0.87 | SLC6A9 (0.63) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL6105332 | 0.86 | SLC6A9 (0.65) | SLC6A9KCNH2SLC6A5CYP3A4CYP2D6 | |
| SCHEMBL15967152 | 0.85 | SLC6A9 (0.52) | SLC6A9KCNH2SLC6A5CYP3A4CYP2D6 | |
| SCHEMBL15967057 | 0.83 | SLC6A9 (0.58) | SLC6A9KCNH2SLC6A5CYP3A4CYP2D6 | |
| SCHEMBL15967139 | 0.83 | SLC6A9 (0.49) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL15967302 | 0.82 | SLC6A9 (0.49) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL15967170 | 0.82 | SLC6A9 (0.52) | SLC6A9KCNH2SLC6A5PSEN1PSEN2 | |
| SCHEMBL15966993 | 0.82 | SLC6A9 (0.49) | SLC6A9KCNH2SLC6A5CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |