Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 17/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967015 | 0.94 | SLC6A9 (0.65) | SLC6A9KCNH2CYP3A4CYP2D6SLC6A5 | |
| SCHEMBL15967195 | 0.92 | SLC6A9 (0.62) | SLC6A9KCNH2CYP3A4CYP2D6SLC6A5 | |
| SCHEMBL15967120 | 0.92 | SLC6A9 (0.60) | SLC6A9KCNH2CYP2D6SLC6A5 | |
| Hydrochloric Acid SCHEMBL15967314 | 0.90 | SLC6A9 (0.72) | SLC6A9KCNH2CYP3A4CYP2D6SLC6A5 | |
| SCHEMBL15966970 | 0.89 | SLC6A9 (0.58) | SLC6A9KCNH2CYP3A4CYP2D6SLC6A5 | |
| SCHEMBL15966913 | 0.89 | SLC6A9 (0.63) | SLC6A9KCNH2CYP3A4CYP2D6SLC6A5 | |
| SCHEMBL15967385 | 0.88 | SLC6A9 (0.72) | SLC6A9KCNH2CYP2D6SLC6A5 | |
| SCHEMBL15967125 | 0.88 | SLC6A9 (0.58) | SLC6A9KCNH2CYP2D6SLC6A5KAT8 | |
| SCHEMBL15967269 | 0.84 | SLC6A9 (0.52) | SLC6A9KCNH2 | |
| Pf-03463275 SCHEMBL23815721 | 0.84 | SLC6A9 (1.00) | SLC6A9KCNH2CYP3A4CYP2D6SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |