Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.61 |
| ▸ | HMGCR | P04035 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 4/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL874695 | 1.00 | PTPN7 (0.61) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL28077752 | 0.98 | PTPN7 (0.59) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL873829 | 0.98 | HMGCR (0.57) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Acetic Acid SCHEMBL28886472 | 0.91 | HMGCR (0.55) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL28984116 | 0.91 | HMGCR (0.50) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL15967903 | 0.88 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL15967786 | 0.88 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| Bicarbonate SCHEMBL15967688 | 0.88 | PTPN7 (0.75) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| SCHEMBL9015838 | 0.88 | PTPN7 (0.48) | PTPN7HMGCRTDP1RECQLALDH1A1 | |
| SCHEMBL54883 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302014-A1 | WASP PEST MANAGEMENT SYSTEM | TONER DARADH (IE) | 2025-10-02 | — | — | US | disclosed |
| EP-4518647-A1 | WASP PEST MANAGEMENT SYSTEM | Toner, Daradh (IE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023214095-A1 | WASP PEST MANAGEMENT SYSTEM | TONER DARADH (IE) | 2023-11-09 | — | — | WO | disclosed |