Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoxitin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.85 |
| ▸ | MAPT | P10636 | 6/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | POLB | P06746 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.55 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.55 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoxitin SCHEMBL20538862 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL11223104 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489250 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL7766649 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL13483263 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489255 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489265 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL3825166 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489240 | 0.99 | NR1I2 (0.98) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL41179 | 0.99 | NR1I2 (0.98) | NR1I2PPARGTDP1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33747 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| CN-122071712-A | Beta-lactam antibiotic whole-cell biosensor, construction method and application | 中国科学院天津工业生物技术研究所 | 2026-05-22 | — | — | CN | claimed |
| CN-115215923-B | Macrocyclic broad-spectrum antibiotics | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | claimed |
| EP-4739326-A2 | PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA | SNIPR Biome ApS (DK) | 2026-05-13 | — | — | EP | claimed |
| US-20260124268-A1 | QUORUM-SENSING INHIBITORS AND/OR POSTBIOTIC METABOLITES AND RELATED METHODS | MICROSINTESIS INC (CA) | 2026-05-07 | — | — | US | claimed |
| EP-4736859-A1 | ANTIBIOTIC COMPOSITIONS | University of Galway (IE) | 2026-05-06 | — | — | EP | claimed |
| US-20260115234-A1 | PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA | SNIPR BIOME APS (DK) | 2026-04-30 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-20260108571-A1 | MYCOBACTERIOPHAGE COMPOSITIONS AND RELATED METHODS | OREGON STATE UNIVERSITY (US) | 2026-04-23 | — | — | US | claimed |
| EP-4101296-B1 | NORMOTHERMIC MACHINE ORGAN PERFUSION FLUID AND PREPARATION METHOD THEREFOR | BIOS CHANGZHOU BIOTECHNOLOGY CO LTD (CN) | 2026-04-15 | — | — | EP | claimed |
| EP-0004925-B1 | SYNERGISTIC MIXTURES OF ANTIBIOTICS AND PROCESS FOR THEIR PRODUCTION | CIBA-GEIGY AG (CH) | 1982-02-24 | — | — | EP | claimed |
| EP-0036534-A1 | An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-30 | — | — | EP | claimed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | claimed |
| EP-0026409-A1 | Combinations of active ingredients, pharmaceutical preparations, as well as their preparation | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-08 | — | — | EP | claimed |
| US-4206202-A | ANTIBIOTIC MM13902 FROM STREPTOMYCES OLIVACEUS | BEECHAM GROUP LIMITED (GB) | 1980-06-03 | — | — | US | claimed |
| EP-0004925-A1 | Synergistic mixtures of antibiotics and process for their production | CIBA-GEIGY AG (CH) | 1979-10-31 | — | — | EP | claimed |
| US-4143134-A | BACTERICIDES, ANTIBIOTIC POTENTIATORS | HOFFMANN-LA ROCHE INC. (US) | 1979-03-06 | — | — | US | claimed |
| US-4100275-A | PEPTIDES | HOFFMANN-LA ROCHE INC. (US) | 1978-07-11 | — | — | US | claimed |
| US-4028355-A | Cephalosporin purification process | SMITHKLINE CORPORATION (US) | 1977-06-07 | — | — | US | claimed |
| US-3937655-A | Method for preparing stable β-lactam-type-antibiotic susceptibility test discs | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | claimed |