Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoxitin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.85 |
| ▸ | MAPT | P10636 | 6/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | POLB | P06746 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.55 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.55 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoxitin SCHEMBL20538862 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL11223104 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489250 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL7766649 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL13483263 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489255 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489265 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL15971 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489240 | 0.99 | NR1I2 (0.98) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL41179 | 0.99 | NR1I2 (0.98) | NR1I2PPARGTDP1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748049-B1 | Process for preparing cefoxitin | ACS DOBFAR SPA (IT) | 2009-09-09 | — | — | EP | disclosed |
| US-20060252928-A1 | Process for the preparation of cefoxitin | ORCHID CHEMICALS AND PHARMACEUTICALS LTD. (IN) | 2006-11-09 | — | — | US | disclosed |
| US-4564676-A | Process for preparing cephalosporin derivatives | SANKYO COMPANY LIMITED (JP) | 1986-01-14 | — | — | US | disclosed |
| US-4390693-A | BACTERICIDE | MERCK & CO., INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4343937-A | ANTIBIOTICS, BACTERICIDES | MERCK & CO., INC. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4342869-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342757-A | Cephalosporin antibiotic compositions | MERCK & CO., INC. (US) | 1982-08-03 | — | — | US | disclosed |
| US-4338437-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4338438-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4324890-A | ANTIBIOTICS, BACTERICIDES | MERCK & CO., INC. (US) | 1982-04-13 | — | — | US | disclosed |
| US-4058661-A | 7-Diacyl cephalosporins | MERCK & CO., INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-4053286-A | ACYLATION | MERCK & CO., INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4053286-A | ACYLATION | MERCK & CO., INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4042472-A | Electrolytic process for 7-methoxy-3-exomethylenecepham compounds | ELI LILLY AND COMPANY (US) | 1977-08-16 | — | — | US | disclosed |
| US-4031085-A | Preparation of 3-hydroxymethyl-7β-aminoadipoyl-7α-methoxy-3-cephem-4-carboxylic acid | MERCK & CO., INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4028355-A | Cephalosporin purification process | SMITHKLINE CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-4014873-A | Process for the production of 7-acylamidocephalosporins | MERCK & CO., INC. (US) | 1977-03-29 | — | — | US | disclosed |
| US-3974151-A | Cephalosporin compounds | MERCK & CO., INC. (US) | 1976-08-10 | — | — | US | disclosed |
| US-3962224-A | CHEMICAL INTERMEDIATES FOR ANTIBIOTICS | MERCK & CO., INC. (US) | 1976-06-08 | — | — | US | disclosed |
| US-3960845-A | HALOGENATION | SANKYO COMPANY LIMITED (JA) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252928-A1 | Process for the preparation of cefoxitin | CYP2F1, CYP2C9, CYP2C19 | NR1I2 2293/4885PPARG 3948/4885TDP1 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.