Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoxitin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.85 |
| ▸ | MAPT | P10636 | 6/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | POLB | P06746 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.55 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.55 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoxitin SCHEMBL20538862 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL11223104 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489250 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL7766649 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL13483263 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489265 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL15971 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL3825166 | 1.00 | NR1I2 (1.00) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL9489240 | 0.99 | NR1I2 (0.98) | NR1I2PPARGTDP1HSD17B10MAPT | |
| Cefoxitin SCHEMBL41179 | 0.99 | NR1I2 (0.98) | NR1I2PPARGTDP1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189157-A | ANTIBACTERIAL CEPHALOSPORIN COMPOUNDS | HOFFMANN LA ROCHE INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0083032-B1 | RECTALLY ADMINISTRABLE SUPPOSITORY COMPRISING A DRUG AND AN ADJUVANT | MERCK & CO. INC. (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4470980-A | Method of increasing oral absorption of β-lactam antibiotics | INTERX RESEARCH CORP. (US) | 1984-09-11 | — | — | US | disclosed |
| EP-0036534-A1 | An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-30 | — | — | EP | disclosed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | disclosed |