Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | HPGD | P15428 | 9/20 | 0.65 |
| ▸ | TSHR | P16473 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | STS | P08842 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | FHIT | P49789 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708735 | 0.81 | KDM4E (0.95) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL10766080 | 0.75 | KDM4E (0.70) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL23493981 | 0.75 | ALDH1A1 (0.78) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL31307822 | 0.75 | ALDH1A1 (0.78) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL15971776 | 0.74 | ALDH1A1 (0.77) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL15971892 | 0.74 | ALDH1A1 (0.77) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL7438868 | 0.74 | TDP1 (0.75) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL15971987 | 0.73 | ALDH1A1 (0.75) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL13799892 | 0.73 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL4708959 | 0.72 | KMT2A (1.00) | ALDH1A1HSD17B10KDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958906-A1 | 3-SUBSTITUTED-6H-BENZO[C]CHROMEN-6-ONES AND 3-SUBSTITUTED-7,8,9,10-TETRAHYDRO-6H-BENZO[C]CHROMEN-6-ONES AGAINST SENILE DEMENTIA | Nobel Ilaç Sanayii Ve Ticaret A.S. (TR) | 2015-12-30 | — | — | EP | claimed |
| WO-2014129989-A1 | 3-SUBSTITUTED-6H-BENZO[C]CHROMEN-6-ONES AND 3-SUBSTITUTED-7,8,9,10-TETRAHYDRO-6H-BENZO[C]CHROMEN-6-ONES AGAINST SENILE DEMENTIA | FARGEM FARMASÖTİK ARAŞTIRMA GELİŞTİRME MERKEZİ SANAYİ VE TİCARET A.Ş. (TR) | 2014-08-28 | — | — | WO | claimed |