Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 7/20 | 0.38 |
| ▸ | CHUK | O15111 | 4/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15973382 | 0.89 | MCL1 (0.50) | MCL1DHODHMGLLPPARG | |
| SCHEMBL15987100 | 0.88 | IKBKB (0.47) | PIK3R2IKBKBCHUKIKBKEPKMYT1 | |
| SCHEMBL29717601 | 0.81 | MCL1 (0.40) | MCL1IKBKBCHUKIKBKEPKMYT1 | |
| SCHEMBL15973598 | 0.81 | MCL1 (0.40) | MCL1IKBKBCHUKIKBKEPKMYT1 | |
| SCHEMBL25939453 | 0.81 | PIK3R2 (0.41) | MCL1PIK3R2IKBKBCHUKIKBKE | |
| SCHEMBL15973388 | 0.80 | MCL1 (0.41) | MCL1PIK3R2IKBKBCHUKIKBKE | |
| SCHEMBL23266846 | 0.79 | MGLL (0.34) | MCL1MGLLJAK3BACE1CA12 | |
| SCHEMBL17909988 | 0.77 | DHODH (0.49) | MCL1DHODH | |
| SCHEMBL23645732 | 0.74 | MCL1 (0.50) | MCL1IKBKBCHUKIKBKEPKMYT1 | |
| SCHEMBL15987102 | 0.74 | IKBKB (0.48) | PIK3R2IKBKBCHUKIKBKEPKMYT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019482-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2016-05-18 | — | — | EP | claimed |
| WO-2014128669-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-28 | — | — | WO | claimed |
| US-11717512-B2 | Methods of use for trisubstituted benzotriazole derivatives | SERVIER PHARMACEUTICALS LLC (US) | 2023-08-08 | — | — | US | disclosed |
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |
| US-11147801-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2021-10-19 | — | — | US | disclosed |
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |
| US-20210113531-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES | SERVIER PHARMACEUTICALS LLC | 2021-04-22 | — | — | US | disclosed |
| EP-3615027-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2020-03-04 | — | — | EP | disclosed |
| WO-2019164794-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES | AGIOS PHARMACEUTICALS, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| US-20190105304-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2019-04-11 | — | — | US | disclosed |
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-01-25 | — | — | US | disclosed |
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-01-25 | — | — | US | disclosed |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-08-10 | — | — | US | disclosed |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-08-10 | — | — | US | disclosed |
| US-9630932-B2 | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2017-04-25 | — | — | US | disclosed |
| US-9630932-B2 | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2017-04-25 | — | — | US | disclosed |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2016-07-14 | — | — | US | disclosed |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2016-07-14 | — | — | US | disclosed |
| WO-2014128669-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | DHODH, DHFR, DPYD | MCL1 1087/4885PIK3R2 4287/4885IKBKB 721/4885 |
| US-11717512-B2 | Methods of use for trisubstituted benzotriazole derivatives | BRDT, BRPF3, BRD4 | MCL1 52/4885PIK3R2 2547/4885IKBKB 1889/4885 |
| US-20190105304-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | DHODH, DHFR, DPYD | MCL1 1087/4885PIK3R2 4287/4885IKBKB 721/4885 |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | DHODH, HAAO, TALDO1 | MCL1 3570/4885PIK3R2 2844/4885IKBKB 869/4885 |
| US-11147801-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | DHODH, DHFR, DDO | MCL1 1219/4885PIK3R2 4453/4885IKBKB 1302/4885 |
| US-20210113531-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES | BRDT, BRPF3, BRD4 | MCL1 52/4885PIK3R2 2547/4885IKBKB 1889/4885 |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | DHODH, DHFR, DDO | MCL1 1219/4885PIK3R2 4453/4885IKBKB 1302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.