Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11977719 | 0.92 | BRD4 (0.38) | BRD4PDE2AMTNR1AMTNR1BTLR9 | |
| SCHEMBL11979678 | 0.87 | MCL1 (0.50) | BRD4MCL1 | |
| SCHEMBL3708601 | 0.86 | MTNR1A (0.39) | PDE2AMTNR1AMTNR1BNR3C1 | |
| SCHEMBL11979686 | 0.86 | MCL1 (0.50) | BRD4MCL1 | |
| SCHEMBL4568428 | 0.86 | TLR9 (0.41) | PDE2AMTNR1AMTNR1BTLR9TLR8 | |
| SCHEMBL11978670 | 0.86 | DGAT1 (0.41) | PDE2AMTNR1AMTNR1BTLR9TLR7 | |
| SCHEMBL15975137 | 0.85 | PDE2A (0.38) | BRD4PDE2AMTNR1AMTNR1BTLR9 | |
| SCHEMBL15975092 | 0.84 | MTNR1A (0.44) | MCL1MTNR1AMTNR1B | |
| SCHEMBL11978663 | 0.84 | BRD4 (0.42) | BRD4MCL1 | |
| SCHEMBL15975189 | 0.84 | MCL1 (0.52) | BRD4MCL1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |