Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 15/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12196113 | 0.77 | EPHX1 (0.58) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12827371 | 0.76 | CYP2C9 (0.46) | TSHR | |
| SCHEMBL4981626 | 0.75 | KDM5A (0.41) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4388519 | 0.75 | CYP2C9 (0.51) | SMN1; SMN2TSHRKDM4EALDH1A1 | |
| SCHEMBL9977773 | 0.74 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL31483078 | 0.74 | CYP2C9 (0.54) | TSHR | |
| SCHEMBL12827372 | 0.74 | CYP2C9 (0.44) | TSHR | |
| SCHEMBL7719657 | 0.72 | NAMPT (0.37) | SMN1; SMN2TSHRKDM4EALDH1A1KMT2A | |
| SCHEMBL359825 | 0.72 | KDM5A (0.44) | — | |
| SCHEMBL29985594 | 0.71 | ACHE (0.43) | TSHRKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815951-B2 | Inhibitors of epoxide hydrolases for the treatment of inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |