SCHEMBL15977

SCHEMBL15977

Nc1ccc(Nc2ccc(Cc3ccc(Nc4ccc(N)cc4)cc3)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.70
ALDH1A1 P00352 3/20 0.70
TSHR P16473 1/20 0.70
TDP1 Q9NUW8 1/20 0.70
MAPT P10636 4/20 0.58
HTT P42858 3/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
CYP1A2 P05177 1/20 0.58
CYP2C9 P11712 1/20 0.58
ALOX12 P18054 1/20 0.58
CYP2C19 P33261 1/20 0.58
RAD52 P43351 1/20 0.54
NR4A1 P22736 1/20 0.50
CYP17A1 P05093 1/20 0.48
CYP19A1 P11511 1/20 0.48
CYP11B1 P15538 1/20 0.48
CYP11B2 P19099 1/20 0.48
GFER P55789 1/20 0.48
LOXL2 Q9Y4K0 1/20 0.46
HPGD P15428 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31285785 1.00 CYP3A4 (0.70) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL31396093 0.91 MAPT (0.75) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL19987394 0.89 CYP3A4 (0.56) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL19987393 0.89 ALDH1A1 (0.56) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL6362775 0.84 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL3482770 0.84 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRTDP1MAPT
4,4'-Methylenedianiline SCHEMBL28001 0.84 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL1304762 0.84 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRTDP1MAPT
SCHEMBL8094139 0.84 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRTDP1MAPT
4,4'-Methylenedianiline SCHEMBL15105282 0.84 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRTDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2366004-B1 LUBRICATING COMPOSITION CONTAINING A POLYMER FUNCTIONALISED WITH A CARBOXYLIC ACID AND AN AROMATIC POLYAMINE LUBRIZOL CORP (US) 2019-08-07 EP claimed
US-20180037841-A1 LUBRICATING ENGINE OIL FOR IMPROVED WEAR PROTECTION AND FUEL EFFICIENCY EXXONMOBIL RESEARCH AND ENGINEERING COMPANY 2018-02-08 US claimed
EP-3268456-A1 METHOD OF LUBRICATING AN INTERNAL COMBUSTION ENGINE The Lubrizol Corporation (US) 2018-01-17 EP claimed
EP-2431448-B1 Lubricating compositions containing the reaction product of an aromatic amine and a carboxylic functionalised polymer and dispersant LUBRIZOL CORP (US) 2017-11-15 EP claimed
EP-2576741-B1 LUBRICATION METHOD LUBRIZOL CORP (US) 2017-08-23 EP claimed
US-9644167-B2 Lubricating compositions containing a carboxylic functionalised polymer and dispersant THE LUBRIZOL CORPORATION (US) 2017-05-09 US claimed
WO-2016144880-A1 METHOD OF LUBRICATING AN INTERNAL COMBUSTION ENGINE THE LUBRIZOL CORPORATION (US) 2016-09-15 WO claimed
US-20160075966-A1 LUBRICATING COMPOSITIONS CONTAINING A CARBOXYLIC FUNCTIONALISED POLYMER AND DISPERSANT LUBRIZOL CORP (US) 2016-03-17 US claimed
US-8969266-B2 Lubricating composition containing a carboxylic functionalised polymer THE LUBRIZOL CORPORATION (US) 2015-03-03 US claimed
US-20130310287-A1 Lubricating Composition Containing a Carboxylic Functionalised Polymer and Dispersant THE LUBRIZOL CORPORATION (US) 2013-11-21 US claimed
US-8569217-B2 Lubricating composition containing a carboxylic functionalised polymer and dispersant THE LUBRIZOL CORPORATION (US) 2013-10-29 US claimed
US-20130203638-A1 Lubricating Composition Containing a Carboxylic Functionalised Polymer THE LUBRIZOL CORPORATION (US) 2013-08-08 US claimed
US-20120046206-A1 Lubricating Composition Containing a Carboxylic Functionalised Polymer and Dispersant THE LUBRIZOL CORPORATION (US) 2012-02-23 US claimed
EP-2401348-A1 LUBRICATING COMPOSITIONS CONTAINING THE REACTION PRODUCT OF AN AROMATIC AMINE AND A CARBOXYLIC FUNCTIONALISED POLYMER AND DISPERSANT The Lubrizol Corporation (US) 2012-01-04 EP claimed
US-20110306528-A1 Lubricating Composition Containing a Functionalised Carboxylic Polymer THE LUBRIZOL CORPORATION (US) 2011-12-15 US claimed
EP-4488349-B1 AZOLE DERIVATIVES AS LUBRICATING ADDITIVES LUBRIZOL CORP (US) 2026-05-20 EP disclosed
EP-4488349-A2 AZOLE DERIVATIVES AS LUBRICATING ADDITIVES The Lubrizol Corporation (US) 2025-01-08 EP disclosed
WO-2010062842-A1 LUBRICATING COMPOSITION CONTAINING A POLYMER FUNCTIONALISED WITH A CARBOXYLIC ACID AND AN AROMATIC POLYAMINE THE LUBRIZOL CORPORATION (US) 2010-06-03 WO disclosed
US-4213914-A ADDITION-CONDENSATION COPOLYMERS RHONE-POULENC INDUSTRIES (FR) 1980-07-22 US disclosed
US-4147711-A Ethylenic silicon compounds and thermoplastic elastomers obtained therefrom RHONE-POULENC INDUSTRIES (FR) 1979-04-03 US disclosed