Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 2/20 | 0.57 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342377 | 0.90 | PDCD1 (0.54) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| SCHEMBL3255785 | 0.89 | OPRM1 (0.67) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| Properidine SCHEMBL25199 | 0.87 | OPRM1 (0.68) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| SCHEMBL349195 | 0.81 | MEN1 (0.56) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| SCHEMBL343236 | 0.80 | PDCD1 (0.47) | APOBEC3AAPOBEC3G | |
| SCHEMBL24131759 | 0.80 | OPRM1 (0.56) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| SCHEMBL382726 | 0.79 | AKR1C1 (0.53) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| Iodomethane SCHEMBL3898463 | 0.78 | MEN1 (0.53) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| SCHEMBL15977392 | 0.77 | MEN1 (0.45) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 | |
| SCHEMBL14967390 | 0.77 | TSHR (0.41) | APOBEC3AAPOBEC3GOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247725-A1 | IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-08-31 | — | — | US | disclosed |
| US-9493799-B2 | In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-11-15 | — | — | US | disclosed |
| US-9487471-B1 | Synthesis of pyrethroids and pyrethroid-containing compositions | PROVIVI, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160032330-A1 | P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-02-04 | — | — | US | disclosed |
| US-20160002682-A1 | IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES | UNITED STATES DEPARTMENT OF ENERGY | 2016-01-07 | — | — | US | disclosed |
| US-8993262-B2 | In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140242647-A1 | IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-08-28 | — | — | US | disclosed |