Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871280 | 0.91 | KDM4E (0.46) | AXLDDB1CRBNSMN1; SMN2GPR119 | |
| SCHEMBL4676078 | 0.86 | CYP17A1 (0.41) | DDB1CRBNPDE3BPDE3APDE4A | |
| SCHEMBL16061282 | 0.84 | MAPK8 (0.41) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL3939017 | 0.83 | PDE3B (0.50) | DDB1CRBNSMN1; SMN2GPR119PDE3B | |
| SCHEMBL1041630 | 0.83 | GPBAR1 (0.43) | AXLSMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL25395897 | 0.82 | SIRT2 (0.46) | AXLSMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL22923578 | 0.81 | CYP19A1 (0.45) | AXLDDB1CRBNGPR119PDE3B | |
| SCHEMBL26282501 | 0.81 | NPSR1 (0.49) | SMN1; SMN2GPR119PDE3BPDE3AGAA | |
| SCHEMBL25395685 | 0.81 | LMNA (0.40) | AXLSMN1; SMN2GPR119PDE3BPDE3A | |
| SCHEMBL1013558 | 0.81 | GPR119 (0.38) | AXLSMN1; SMN2GPR119PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842424-B1 | MAP KINASE MODULATORS AND USES THEREOF IN THE TRETAMENT OF TAUOPATHIES | UNIV COLUMBIA (US) | 2024-12-11 | — | — | EP | disclosed |
| US-11566016-B2 | MAP kinase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-01-31 | — | — | US | disclosed |
| US-11566016-B2 | MAP kinase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-01-31 | — | — | US | disclosed |
| US-20220009905-A1 | MAP KINASE MODULATORS AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2022-01-13 | — | — | US | disclosed |
| US-20220009905-A1 | MAP KINASE MODULATORS AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2022-01-13 | — | — | US | disclosed |
| US-11149020-B2 | MAP kinase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-10-19 | — | — | US | disclosed |
| US-11149020-B2 | MAP kinase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-10-19 | — | — | US | disclosed |
| EP-3842424-A1 | MAP KINASE MODULATORS AND USES THEREOF IN THE TRETAMENT OF TAUOPATHIES | The Trustees of Columbia University in the City of New York (US) | 2021-06-30 | — | — | EP | disclosed |
| EP-3842424-A1 | MAP KINASE MODULATORS AND USES THEREOF IN THE TRETAMENT OF TAUOPATHIES | The Trustees of Columbia University in the City of New York (US) | 2021-06-30 | — | — | EP | disclosed |
| EP-3521284-B1 | PYRAZINE COMPOUNDS AS MAP KINASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-12-02 | — | — | EP | disclosed |
| US-8188096-B2 | Protein kinase targeted therapeutics | NORTHWESTERN UNIVERSITY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110166153-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166153-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2011-07-07 | — | — | US | disclosed |
| US-7919485-B2 | Protein kinase targeted therapeutics | NORTHWESTERN UNIVERSITY (US) | 2011-04-05 | — | — | US | disclosed |
| US-7919485-B2 | Protein kinase targeted therapeutics | NORTHWESTERN UNIVERSITY (US) | 2011-04-05 | — | — | US | disclosed |
| US-20100016587-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016587-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2010-01-21 | — | — | US | disclosed |
| WO-2008094208-A2 | PROTEIN KINASE TARGETED THERAPEUTICS | NORTHWESTERN UNIVERSITY (US) | 2008-08-07 | — | — | WO | disclosed |
| US-20080051410-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2008-02-28 | — | — | US | disclosed |
| US-20080051410-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166153-A1 | Protein Kinase Targeted Therapeutics | MAP3K1, MAP3K6, MAPK1 | AXL 1940/4885DDB1 867/4885CRBN 754/4885 |
| US-11566016-B2 | MAP kinase modulators and uses thereof | MAPK1, MAP3K1, MAP3K2 | AXL 1414/4885DDB1 1964/4885CRBN 1591/4885 |
| US-11149020-B2 | MAP kinase modulators and uses thereof | MAPK1, MAP3K1, MAP3K2 | AXL 1414/4885DDB1 1964/4885CRBN 1591/4885 |
| US-20100016587-A1 | Protein Kinase Targeted Therapeutics | MAP3K1, MAP3K6, MAPK1 | AXL 1940/4885DDB1 867/4885CRBN 754/4885 |
| US-20220009905-A1 | MAP KINASE MODULATORS AND USES THEREOF | MAPK1, MAP3K1, MAP3K2 | AXL 1414/4885DDB1 1964/4885CRBN 1591/4885 |
| US-20080051410-A1 | Protein Kinase Targeted Therapeutics | MAP3K1, MAP3K6, MAPK1 | AXL 1940/4885DDB1 867/4885CRBN 754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.