Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 5/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628187 | 0.88 | ESR1 (0.51) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL9725104 | 0.88 | ESR1 (0.51) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL9628599 | 0.85 | LMNA (0.52) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL10644810 | 0.84 | LMNA (0.46) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8056152 | 0.81 | LMNA (0.51) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8055169 | 0.81 | LMNA (0.51) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8059625 | 0.81 | LMNA (0.48) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8056168 | 0.79 | LMNA (0.48) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL10645130 | 0.79 | LMNA (0.50) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8959384 | 0.78 | LMNA (0.53) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987484-B2 | Process for the production of estetrol | ESTETRA S.P.R.L. (BE) | 2015-03-24 | — | — | US | disclosed |
| US-20140243539-A1 | Process for the Production of Estetrol | ESTETRA S.P.R.L. (BE) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243539-A1 | Process for the Production of Estetrol | VKORC1L1, CYP46A1, DHCR7 | LMNA 1969/4885HSD17B1 15/4885MAPT 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.