Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.49 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | PRF1 | P14222 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | TARS1 | P26639 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15984853 | 0.80 | GSK3B (0.56) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL13680668 | 0.77 | CYP1A2 (0.50) | PARP10PARP11CYP2A6TGFBR1GRM5 | |
| SCHEMBL26613487 | 0.77 | PRKCI (0.47) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL13680532 | 0.77 | CLK4 (0.78) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL13680566 | 0.76 | PRF1 (0.52) | PRF1 | |
| SCHEMBL26178248 | 0.76 | PRKCI (0.55) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL5576724 | 0.75 | CLK4 (0.41) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL13680629 | 0.74 | GSK3B (0.52) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL23136945 | 0.73 | BRAF (0.58) | CLK4GSK3BDAPK3NTRK1PIM1 | |
| SCHEMBL30995381 | 0.73 | BRAF (0.58) | CLK4GSK3BDAPK3NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |