Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806745 | 0.89 | IMPDH2 (0.34) | IMPDH2CYP19A1LMNATSHRHSD17B10 | |
| SCHEMBL806744 | 0.80 | KDM4E (0.38) | PTPN1IMPDH2CYP19A1HSD17B10 | |
| SCHEMBL806720 | 0.75 | HTR2A (0.34) | IMPDH2CYP19A1 | |
| SCHEMBL806715 | 0.74 | PTPN1 (0.39) | PTPN1IMPDH2 | |
| SCHEMBL15980405 | 0.73 | BACE1 (0.41) | PTPN1LMNA | |
| SCHEMBL8512148 | 0.69 | LMNA (0.40) | CYP19A1LMNATSHR | |
| SCHEMBL8512153 | 0.69 | LMNA (0.40) | CYP19A1LMNATSHR | |
| SCHEMBL23326179 | 0.69 | TSHR (0.50) | LMNADPP4TSHRHSD17B10 | |
| SCHEMBL806897 | 0.67 | CYP3A4 (0.38) | PTPN1 | |
| SCHEMBL984259 | 0.66 | KDM4E (0.33) | PTPN1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243404-A1 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243404-A1 | UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY | WEE1, WEE2, NOTUM | PTPN1 4764/4885IMPDH2 2395/4885CYP19A1 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.