Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14696925 | 0.93 | GAA (0.68) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL14685767 | 0.92 | GAA (0.66) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL15047160 | 0.88 | HCN4 (0.58) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL30081993 | 0.88 | GAA (0.61) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL14696959 | 0.88 | GAA (0.61) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL9032662 | 0.88 | GAA (0.61) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL10978574 | 0.86 | HCN4 (0.56) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL12319782 | 0.85 | HCN4 (0.71) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL333182 | 0.85 | HCN4 (0.58) | GAASMN1; SMN2HCN4MAPTSLC6A4 | |
| SCHEMBL22738846 | 0.84 | GAA (0.64) | GAASMN1; SMN2HCN4MAPTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006424-B2 | Process for the manufacture of ivabradine and of intermediates of synthesis thereof | LABORATORIO CHIMICO INTERNAZIONALE S.P.A. (IT) | 2015-04-14 | — | — | US | disclosed |
| US-20140357859-A1 | PROCESS FOR THE MANUFACTURE OF IVABRADINE AND OF INTERMEDIATES OF SYNTHESIS THEREOF | LOBORATORIO CHIMICO INTERNAZIONALE S.p.A. (IT) | 2014-12-04 | — | — | US | disclosed |
| US-20140242644-A1 | PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357859-A1 | PROCESS FOR THE MANUFACTURE OF IVABRADINE AND OF INTERMEDIATES OF SYNTHESIS THEREOF | CYP4F2, NISCH, CYP4F3 | GAA 1519/4885SMN1; SMN2 3273/4885HCN4 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.