Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.64 |
| ▸ | SCN1A | P35498 | 1/20 | 0.64 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.64 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 8/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15988308 | 1.00 | ADRA2A (0.64) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567617 | 0.83 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567316 | 0.83 | DRD2 (0.63) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL566715 | 0.83 | DRD2 (0.63) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567706 | 0.82 | DRD2 (0.62) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL3044736 | 0.81 | DRD2 (0.64) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567283 | 0.81 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL3044732 | 0.81 | DRD2 (0.64) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL30495456 | 0.81 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL567626 | 0.81 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176252-B1 | 2, 3-DIHYDROBENZO[1, 4]DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES | ORION CORP (FI) | 2014-09-03 | — | — | EP | claimed |