Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004000 | 0.91 | GPR142 (0.51) | GPR142ALDH1A1LMNAGLAHSD17B10 | |
| SCHEMBL16004318 | 0.90 | GPR142 (0.58) | GPR142ALDH1A1LMNAGLAHSD17B10 | |
| SCHEMBL16003995 | 0.90 | GPR142 (0.49) | GPR142ALDH1A1LMNAGLAHSD17B10 | |
| SCHEMBL16004320 | 0.88 | GPR142 (0.51) | GPR142ALDH1A1LMNAGLAHSD17B10 | |
| SCHEMBL16004323 | 0.86 | GPR142 (0.65) | GPR142ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16004317 | 0.83 | GPR142 (0.61) | GPR142ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16003996 | 0.82 | GPR142 (0.60) | GPR142ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL16003994 | 0.82 | GPR142 (0.60) | GPR142ALDH1A1MAPT | |
| SCHEMBL16004319 | 0.78 | GPR142 (0.60) | GPR142ALDH1A1MAPT | |
| SCHEMBL16004087 | 0.78 | MAPT (0.53) | GPR142ALDH1A1LMNAHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |