Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 8/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004317 | 0.93 | GPR142 (0.61) | GPR142KDM4EALDH1A1MAPTCHRM5 | |
| SCHEMBL16004323 | 0.88 | GPR142 (0.65) | GPR142KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL16003996 | 0.87 | GPR142 (0.60) | GPR142KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL16003992 | 0.85 | KMT2A (0.45) | GPR142ALDH1A1CHRM5CHRM1 | |
| SCHEMBL16004319 | 0.84 | GPR142 (0.60) | GPR142KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL16003995 | 0.83 | GPR142 (0.49) | GPR142ALDH1A1MAPT | |
| SCHEMBL16003990 | 0.83 | CHRM5 (0.43) | GPR142KDM4ECHRM5CHRM1TP53 | |
| SCHEMBL16003997 | 0.82 | GPR142 (0.53) | GPR142ALDH1A1MAPT | |
| SCHEMBL16003993 | 0.80 | GAA (0.51) | GPR142KDM4EALDH1A1CHRM5CHRM1 | |
| SCHEMBL16003986 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPTCHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |