Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004239 | 1.00 | GPR142 (0.47) | GPR142ALDH1A1BLMRIPK1MAPT | |
| SCHEMBL16004234 | 0.89 | GPR142 (0.46) | GPR142RIPK1 | |
| SCHEMBL16004003 | 0.84 | GPR142 (0.47) | GPR142ALDH1A1BLMRIPK1MAPT | |
| SCHEMBL16004007 | 0.83 | GPR142 (0.42) | GPR142ALDH1A1RIPK1MAPTLMNA | |
| SCHEMBL16004008 | 0.83 | GPR142 (0.42) | GPR142ALDH1A1RIPK1MAPTLMNA | |
| SCHEMBL16004014 | 0.83 | GPR142 (0.42) | GPR142ALDH1A1RIPK1MAPTLMNA | |
| SCHEMBL16004318 | 0.80 | GPR142 (0.58) | GPR142ALDH1A1BLMMAPTLMNA | |
| SCHEMBL16003997 | 0.77 | GPR142 (0.53) | GPR142ALDH1A1BLMMAPTLMNA | |
| SCHEMBL16004000 | 0.77 | GPR142 (0.51) | GPR142ALDH1A1BLMMAPTLMNA | |
| SCHEMBL16004165 | 0.76 | GPR142 (0.42) | GPR142ALDH1A1RIPK1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |