Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 13/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16003948 | 0.92 | GPR142 (0.58) | GPR142NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16004223 | 0.84 | GPR142 (0.45) | GPR142SMN1; SMN2HTT | |
| SCHEMBL16003958 | 0.83 | CREBBP (0.56) | — | |
| SCHEMBL16004061 | 0.83 | GPR142 (0.46) | GPR142SMN1; SMN2 | |
| SCHEMBL16003951 | 0.82 | TAAR1 (0.46) | GPR142RAB9A | |
| SCHEMBL16004276 | 0.81 | CREBBP (0.40) | GPR142NPC1RAB9A | |
| SCHEMBL16003957 | 0.81 | GPR142 (0.45) | GPR142NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL16004280 | 0.80 | CREBBP (0.38) | GPR142SMN1; SMN2 | |
| SCHEMBL16004275 | 0.80 | CREBBP (0.43) | GPR142 | |
| SCHEMBL16004281 | 0.80 | CREBBP (0.39) | GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |