Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 13/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16003957 | 0.85 | GPR142 (0.45) | GPR142CREBBPSMN1; SMN2LMNAHTT | |
| SCHEMBL16003958 | 0.84 | CREBBP (0.56) | CREBBPRIPK1 | |
| SCHEMBL16004245 | 0.84 | GPR142 (0.60) | GPR142SMN1; SMN2HTT | |
| SCHEMBL16004414 | 0.84 | CREBBP (0.44) | GPR142CREBBPCYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL16003946 | 0.82 | RIPK1 (0.41) | GPR142CREBBPLMNARIPK1 | |
| SCHEMBL16004411 | 0.82 | HTT (0.46) | GPR142CREBBPCYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL16004070 | 0.82 | GPR142 (0.49) | GPR142CREBBPCYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL16004051 | 0.82 | RIPK1 (0.41) | GPR142CREBBPALDH1A1LMNAHTT | |
| SCHEMBL16003951 | 0.81 | TAAR1 (0.46) | GPR142CREBBPLMNATP53RIPK1 | |
| SCHEMBL16004413 | 0.81 | CREBBP (0.43) | GPR142CREBBPCYP2D6RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |