Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 8/20 | 0.40 |
| ▸ | THRA | P10827 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16005185 | 0.94 | ORAI1 (0.54) | ORAI1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL17513175 | 0.89 | ORAI1 (0.56) | ORAI1ERN1KDM4EALDH1A1TDP1 | |
| SCHEMBL10578387 | 0.84 | S1PR2 (0.49) | S1PR2S1PR1S1PR3LPAR2THRB | |
| SCHEMBL11258112 | 0.84 | S1PR2 (0.49) | S1PR2S1PR1S1PR3LPAR2THRB | |
| SCHEMBL8189636 | 0.82 | ORAI1 (0.51) | ORAI1ERN1THRBALDH1A1TDP1 | |
| SCHEMBL7294470 | 0.82 | ORAI1 (0.49) | ORAI1ERN1KDM4EALDH1A1TDP1 | |
| SCHEMBL5883224 | 0.80 | ORAI1 (0.56) | ORAI1ERN1KDM4EALDH1A1TDP1 | |
| SCHEMBL14195844 | 0.80 | S1PR2 (0.50) | S1PR2S1PR1S1PR3LPAR2THRB | |
| SCHEMBL16005078 | 0.79 | THRA (0.42) | ORAI1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL16004998 | 0.79 | ORAI1 (0.40) | ORAI1S1PR2S1PR1S1PR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2774914-B1 | N-BENZYLANILINE DERIVATIVE AND USES THEREOF | UNIV NANJING MEDICAL (CN) | 2017-12-06 | — | — | EP | disclosed |
| US-9481636-B2 | N-benzylaniline derivative and uses thereof | NANJING MEDICAL UNIVERSITY (CN) | 2016-11-01 | — | — | US | disclosed |
| CN-103086908-B | N-benzylaniline derivatives and application thereof | UNIV NANJING MEDICAL | 2015-05-13 | — | — | CN | disclosed |
| US-20140303248-A1 | N-BENZYLANILINE DERIVATIVE AND USES THEREOF | Neurodawn Pharmaceutical Co., Ltd. (CN) | 2014-10-09 | — | — | US | disclosed |
| EP-2774914-A1 | N-BENZYLANILINE DERIVATIVE AND USES THEREOF | Nanjing Medical University (CN) | 2014-09-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303248-A1 | N-BENZYLANILINE DERIVATIVE AND USES THEREOF | NLN, INA, TRPV1 | ORAI1 169/4885S1PR2 1667/4885S1PR1 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.