Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GRN | P28799 | 1/20 | 0.30 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564810 | 0.90 | EGLN1 (0.36) | EGLN1LMNABCL6NCOR2KDM4E | |
| SCHEMBL3435037 | 0.81 | EGLN1 (0.45) | EGLN1LMNABCL6NCOR2KDM4E | |
| SCHEMBL14575605 | 0.81 | BCL6 (0.35) | EGLN1BCL6NCOR2KDM4ECYP1A2 | |
| SCHEMBL2575235 | 0.80 | HSP90AA1 (0.46) | EGLN1LMNAKDM4ECYP1A2CYP2C19 | |
| SCHEMBL2573169 | 0.77 | NCEH1 (0.41) | — | |
| SCHEMBL2560122 | 0.77 | PORCN (0.42) | EGLN1KDM4ECYP1A2CYP2C19CYP2D6 | |
| SCHEMBL2575436 | 0.76 | ADORA2A (0.42) | EGLN1ADORA2AALDH1A1 | |
| SCHEMBL2575184 | 0.76 | RAB9A (0.41) | EGLN1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL2561208 | 0.76 | MEN1 (0.53) | EGLN1KDM4ECYP1A2CYP2C19CYP2D6 | |
| SCHEMBL2577279 | 0.76 | EGLN1 (0.33) | EGLN1KDM4ECYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-B1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK SHARP & DOHME (US) | 2014-09-10 | — | — | EP | disclosed |