Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4961623 | 0.90 | HTR4 (0.36) | L3MBTL1KDM4EALDH1A1HTR4ALOX15 | |
| SCHEMBL16005740 | 0.85 | HTR4 (0.41) | L3MBTL1KDM4EALDH1A1HTR4ALOX15 | |
| SCHEMBL4199349 | 0.78 | KDM4E (0.33) | KDM4EALDH1A1 | |
| SCHEMBL4206306 | 0.70 | HTR4 (0.33) | KDM4EALDH1A1HTR4NPSR1 | |
| SCHEMBL2446798 | 0.70 | L3MBTL1 (0.42) | L3MBTL1KDM4EHTR4MEN1KMT2A | |
| SCHEMBL4195676 | 0.69 | HTR4 (0.38) | L3MBTL1KDM4EALDH1A1HTR4MEN1 | |
| SCHEMBL2387235 | 0.69 | L3MBTL1 (0.41) | L3MBTL1KDM4EALDH1A1HTR4MEN1 | |
| SCHEMBL31061327 | 0.69 | L3MBTL1 (0.41) | L3MBTL1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL17033124 | 0.69 | L3MBTL1 (0.41) | L3MBTL1KDM4EHTR4MEN1KMT2A | |
| SCHEMBL1667133 | 0.69 | L3MBTL1 (0.45) | L3MBTL1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871772-B1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE INC (US) | 2014-09-10 | — | — | EP | claimed |