Tobramycin

SCHEMBL16011782

COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmE2 rpmF rpmG rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU

The experimentally established mechanism targets of Tobramycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PTGS2	P35354	6/20	0.55

▸	AKR1C3	P42330	5/20	0.55

▸	AKR1C2	P52895	4/20	0.55

▸	PTGS1	P23219	3/20	0.55

▸	MEN1	O00255	2/20	0.55

▸	CYP1A2	P05177	2/20	0.55

▸	CYP2C9	P11712	2/20	0.55

▸	PMP22	Q01453	2/20	0.55

▸	KMT2A	Q03164	2/20	0.55

▸	GLO1	Q04760	2/20	0.55

▸	HIF1A	Q16665	2/20	0.55

▸	ABCB1	P08183	2/20	0.55

▸	KDM4E	B2RXH2	1/20	0.55

▸	PTGES	O14684	1/20	0.55

▸	ABCC3	O15438	1/20	0.55

▸	ABCC4	O15439	1/20	0.55

▸	ABCB11	O95342	1/20	0.55

▸	MT-CO2	P00403	1/20	0.55

▸	LMNA	P02545	1/20	0.55

▸	ALB	P02768	1/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16009661	0.90	PTGS2 (0.53)	PTGS2AKR1C3PTGS1GLO1HIF1A
SCHEMBL16024207	0.90	PTGS2 (0.53)	PTGS2AKR1C3PTGS1GLO1HIF1A
SCHEMBL16017874	0.89	PTGS2 (0.52)	PTGS2AKR1C3PTGS1GLO1HIF1A
SCHEMBL16010034	0.86	PTGS2 (0.53)	PTGS2AKR1C3PTGS1GLO1HIF1A
Indomethacin SCHEMBL5492772	0.81	PTGS2 (0.64)	PTGS2AKR1C3AKR1C2PTGS1MEN1
Indomethacin SCHEMBL28124710	0.79	AKR1C3 (0.69)	PTGS2AKR1C3AKR1C2PTGS1MEN1
Betadex SCHEMBL11491489	0.75	AKR1C3 (0.71)	PTGS2AKR1C3AKR1C2PTGS1MEN1
Betadex SCHEMBL30950731	0.75	AKR1C3 (0.71)	PTGS2AKR1C3AKR1C2PTGS1MEN1
Indomethacin SCHEMBL29525957	0.74	PTGS2 (1.00)	PTGS2AKR1C3AKR1C2PTGS1MEN1
Indomethacin SCHEMBL29353712	0.74	PTGS2 (1.00)	PTGS2AKR1C3AKR1C2PTGS1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2964265-A1	ANTIBIOTIC CONJUGATES WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS	ALLERGAN, INC. (US)	2016-01-13	—	—	EP	disclosed
WO-2014138343-A1	ANTIBIOTIC CONJUGATES WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS	ALLERGAN, INC. (US)	2014-09-12	—	—	WO	disclosed