Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indomethacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 9/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 4/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 7/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | GLO1 | Q04760 | 2/20 | 1.00 |
| ▸ | AKR1C4 | P17516 | 2/20 | 1.00 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | PTGES | O14684 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indomethacin SCHEMBL29525957 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL3518614 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL9300 | 1.00 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL6356562 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL1817813 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23632959 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL8352438 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL22472310 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL3860125 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A | |
| Indomethacin SCHEMBL23391006 | 0.99 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2PTGS1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 543 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076889-A1 | POLYESTER FILM-FORMING POLYMERS FOR ALCOHOLBASED SUNSCREEN FORMULATIONS | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2026-03-19 | — | — | US | claimed |
| US-20250381126-A1 | POLYVINYL ALCOHOL FILM-FORMING POLYMERS FOR ALCOHOL-BASED SUNSCREEN FORMULATIONS AND METHODS OF USING SAME | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2025-12-18 | — | — | US | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| EP-4577180-A1 | POLYESTER FILM-FORMING POLYMERS FOR ALCOHOL-BASED SUNSCREEN FORMULATIONS | Nouryon Chemicals International B.V. (NL) | 2025-07-02 | — | — | EP | claimed |
| US-12290590-B2 | Biodegradable polyesters for water-resistant anhydrous suncare formulations | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2025-05-06 | — | — | US | claimed |
| US-12287324-B2 | Companion diagnostics for NSAIDS and donepezil for treating specific subpopulations of patients suffering from Alzheimer's disease | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) | 2025-04-29 | — | — | US | claimed |
| CN-119744162-A | Polyester film-forming polymers for alcohol-based sunscreen formulations | 诺力昂化学品国际有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119522090-A | Polyvinyl alcohol film-forming polymers for alcohol-based sunscreen formulations and methods of use thereof | 诺力昂化学品国际有限公司 | 2025-02-25 | — | — | CN | claimed |
| WO-2024258363-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | SAHIN FIKRET (TR) | 2024-12-19 | — | — | WO | claimed |
| CN-119112769-A | Synthesis method of light-responsive multiple drug-loaded nanogel | 中山大学附属第八医院（深圳福田） | 2024-12-13 | — | — | CN | claimed |
| WO-2023059810-A1 | STENTS AND METHODS OF USE | UNIVERSITY OF CONNECTICUT (US) | 2023-04-13 | — | — | WO | claimed |
| WO-2023044463-A1 | SILK FIBROIN DERIVED BRUSH-LIKE POLYMERS | UNIVERSITY OF CONNECTICUT (US) | 2023-03-23 | — | — | WO | claimed |
| US-20220347208-A1 | FORMULATIONS USING LITHIUM TO TREAT GOUT ARTHROPATHY | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2022-11-03 | — | — | US | claimed |
| CN-115044541-A | High-differentiation-efficiency immortalized pig fat precursor cell line and construction method and application thereof | 南京农业大学 | 2022-09-13 | — | — | CN | claimed |
| EP-4034136-A1 | FORMULATIONS USING LITHIUM TO TREAT GOUT ARTHROPATHY | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2022-08-03 | — | — | EP | claimed |
| CN-114832082-A | Traditional Chinese medicine preparation for treating pyretic arthralgia and preparation process thereof | 海南省中医院 | 2022-08-02 | — | — | CN | claimed |
| CN-114601930-A | Combination therapy of PD-1 signaling inhibitors | 国立大学法人京都大学 | 2022-06-10 | — | — | CN | claimed |
| CN-114404595-A | Combination therapy of PD-1 signaling inhibitors | 国立大学法人京都大学 | 2022-04-29 | — | — | CN | claimed |
| US-20220107305-A1 | Companion Diagnostics for NSAIDS and Donepezil for Treating Specific Subpopulations of Patients Suffering from Alzheimer's Disease | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH | 2022-04-07 | — | — | US | claimed |
| US-11234927-B2 | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia | MEDIPRINT OPHTHALMICS INC. | 2022-02-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250381126-A1 | POLYVINYL ALCOHOL FILM-FORMING POLYMERS FOR ALCOHOL-BASED SUNSCREEN FORMULATIONS AND METHODS OF USING SAME | VAPA, TTPA, ADH1A | PTGS2 2505/4885PTGS1 2517/4885AKR1C3 649/4885 |
| US-20260076889-A1 | POLYESTER FILM-FORMING POLYMERS FOR ALCOHOLBASED SUNSCREEN FORMULATIONS | ELOVL3, POLD3, TAF1 | PTGS2 1232/4885PTGS1 1794/4885AKR1C3 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.