Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093300 | 0.80 | ADORA3 (0.68) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| SCHEMBL8093292 | 0.80 | ADORA3 (0.68) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| SCHEMBL14759262 | 0.79 | AR (0.73) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| SCHEMBL12067046 | 0.75 | MAOB (0.71) | ARCYP3A4ADORA3MAOBCYP19A1 | |
| SCHEMBL5082108 | 0.73 | AR (1.00) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| SCHEMBL5082116 | 0.73 | AR (0.80) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| SCHEMBL14759121 | 0.73 | SLC8A1 (0.46) | — | |
| 2'-Hydroxy-Flavanone SCHEMBL128288 | 0.72 | AR (1.00) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| 2'-Hydroxy-Flavanone SCHEMBL128289 | 0.72 | AR (1.00) | ARCYP3A4ADORA3HSD11B1AKR1C3 | |
| 2'-Hydroxy-Flavanone SCHEMBL29661236 | 0.72 | AR (1.00) | ARCYP3A4ADORA3HSD11B1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008341-B | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | 赛诺菲 | 2017-10-24 | — | — | CN | disclosed |
| US-20170166548-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2017-06-15 | — | — | US | disclosed |
| EP-2964623-B1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2016-11-02 | — | — | EP | disclosed |
| US-9440941-B2 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2016-09-13 | — | — | US | disclosed |
| US-20160016928-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | SANOFI (FR) | 2016-01-21 | — | — | US | disclosed |
| EP-2964623-A1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135674-A1 | SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016928-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | RYR2, RYR1, CACNA1E | AR 912/4885CYP3A4 1023/4885ADORA3 317/4885 |
| US-20170166548-A1 | Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals | RYR2, RYR1, CACNA1E | AR 902/4885CYP3A4 999/4885ADORA3 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.