Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674873 | 0.77 | BTK (0.58) | BTKCLK2KDM4ERAB9A | |
| SCHEMBL3654050 | 0.77 | BTK (0.50) | BTKCLK2SRCKDM4ERAB9A | |
| SCHEMBL3665173 | 0.74 | BTK (0.51) | BTKCLK2SRCKDM4ERAB9A | |
| SCHEMBL1726615 | 0.73 | BTK (0.61) | BTK | |
| SCHEMBL1725221 | 0.72 | BTK (0.75) | BTKCLK2 | |
| SCHEMBL16013978 | 0.72 | BTK (0.74) | BTKCLK2SRCKDM4ERAB9A | |
| SCHEMBL3672695 | 0.72 | BTK (0.61) | BTKCLK2SRCKDM4ERAB9A | |
| SCHEMBL1725887 | 0.71 | BTK (0.77) | BTKCLK2 | |
| SCHEMBL3666556 | 0.70 | BTK (0.60) | BTKKDM4ERAB9A | |
| SCHEMBL3671891 | 0.68 | BTK (0.56) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964642-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135474-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |