Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17394163 | 0.73 | HTR6 (0.36) | HTR6 | |
| SCHEMBL17402825 | 0.71 | — | — | |
| SCHEMBL12994620 | 0.71 | FABP4 (0.54) | HTR6RAPGEF4POLBL3MBTL1MAPT | |
| SCHEMBL8386471 | 0.69 | PRKCI (0.55) | HTR6RAPGEF4POLBL3MBTL1MAPT | |
| SCHEMBL3021216 | 0.69 | FABP4 (0.52) | HTR6RAPGEF4POLBL3MBTL1HTT | |
| SCHEMBL2302805 | 0.69 | HTR6 (0.42) | HTR6RAPGEF4POLBL3MBTL1MAPT | |
| SCHEMBL8503313 | 0.67 | HTR6 (0.44) | HTR6RAPGEF4POLBL3MBTL1MAPT | |
| SCHEMBL17812873 | 0.67 | HTR6 (0.45) | HTR6RAPGEF4POLBL3MBTL1MAPT | |
| SCHEMBL3217384 | 0.66 | HTR6 (0.45) | HTR6RAPGEF4L3MBTL1MAPTHTT | |
| SCHEMBL20946417 | 0.66 | HTR6 (0.42) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964635-A1 | ANTIVIRAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135495-A1 | ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |