Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16014470 | 0.78 | MKNK1 (1.00) | MKNK1CDC7 | |
| SCHEMBL16013693 | 0.73 | MKNK1 (1.00) | MKNK1ROCK2ROCK1 | |
| SCHEMBL3582360 | 0.71 | ROCK2 (0.64) | MKNK1ROCK2ROCK1ULK1 | |
| SCHEMBL16013611 | 0.71 | MKNK1 (1.00) | MKNK1ROCK2ROCK1 | |
| SCHEMBL12964961 | 0.69 | SYK (0.49) | ULK1POLBSYK | |
| SCHEMBL28439881 | 0.68 | ROCK2 (0.59) | ROCK2ROCK1SYK | |
| SCHEMBL28449443 | 0.68 | ROCK2 (0.59) | MKNK1ROCK2ROCK1 | |
| SCHEMBL22201378 | 0.68 | ROCK2 (0.62) | MKNK1ROCK2ROCK1ULK1 | |
| SCHEMBL14320774 | 0.67 | ROCK1 (0.47) | MKNK1ROCK2ROCK1 | |
| SCHEMBL18056619 | 0.66 | ROCK2 (1.00) | MKNK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964656-A1 | SUBSTITUTED THIAZOLOPYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135480-A1 | SUBSTITUTED THIAZOLOPYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-09-12 | — | — | WO | disclosed |