Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.62 |
| ▸ | ULK1 | O75385 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582360 | 0.94 | ROCK2 (0.64) | ROCK2ULK1TGFBR1PDE5APAK4 | |
| SCHEMBL22201371 | 0.79 | ROCK2 (0.68) | ROCK2TGFBR1ROCK1 | |
| SCHEMBL22201445 | 0.79 | ROCK2 (0.51) | ROCK2ULK1TGFBR1ROCK1 | |
| SCHEMBL22201435 | 0.78 | PDE5A (0.46) | ROCK2ULK1TGFBR1PDE5APAK4 | |
| SCHEMBL7091416 | 0.78 | TGFBR1 (0.63) | ROCK2ULK1TGFBR1PAK4ROCK1 | |
| SCHEMBL3586643 | 0.78 | TGFBR1 (0.63) | ROCK2ULK1TGFBR1PAK4ROCK1 | |
| SCHEMBL29445613 | 0.78 | TGFBR1 (0.63) | ROCK2ULK1TGFBR1PAK4ROCK1 | |
| SCHEMBL3585107 | 0.78 | TGFBR1 (0.69) | ROCK2ULK1TGFBR1PAK4ROCK1 | |
| SCHEMBL22126148 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL30611475 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |