Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564336 | 0.80 | PKM (0.45) | LMNADAOALDH1A1GAAHPGD | |
| SCHEMBL18721350 | 0.78 | LMNA (0.64) | LMNAALDH1A1GAAMAPTL3MBTL1 | |
| SCHEMBL131869 | 0.75 | — | — | |
| SCHEMBL13925528 | 0.75 | — | — | |
| SCHEMBL890877 | 0.75 | — | — | |
| SCHEMBL16016316 | 0.74 | IDO1 (0.41) | DAOALDH1A1GAAPKMIDO1 | |
| SCHEMBL752766 | 0.73 | DAO (0.41) | LMNADAOALDH1A1GAAHPGD | |
| Ammonia Solution, Strong SCHEMBL143304 | 0.73 | LMNA (0.70) | LMNAALDH1A1GAAMAPTL3MBTL1 | |
| SCHEMBL12531367 | 0.72 | ERCC1 (0.46) | ALDH1A1GAAHPGDMAPTGCGR | |
| SCHEMBL16016412 | 0.72 | LMNA (0.43) | LMNADAOALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2774928-B1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2017-08-30 | — | — | EP | disclosed |
| EP-2774928-A1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2014-09-10 | — | — | EP | disclosed |