Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887603 | 0.93 | REN (0.40) | SMN1; SMN2MAPK14ALDH1A1GAAMAPT | |
| SCHEMBL14887607 | 0.89 | MEN1 (0.38) | SMN1; SMN2MAPK14ALDH1A1GAAMAPT | |
| SCHEMBL14887604 | 0.88 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPK14ALDH1A1GAAMAPT | |
| SCHEMBL16017305 | 0.86 | ALDH1A1 (0.43) | SMN1; SMN2MAPK14ALDH1A1GAAMAPT | |
| SCHEMBL14887600 | 0.81 | MEN1 (0.47) | SMN1; SMN2ALDH1A1GAAMAPTAPEX1 | |
| SCHEMBL16017439 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2MAPK14ALDH1A1GAAMAPT | |
| SCHEMBL14879688 | 0.75 | MPL (0.39) | ALDH1A1GAAMAPTRAB9APTGS1 | |
| SCHEMBL16017301 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1GAAMAPTRAB9A | |
| SCHEMBL14879431 | 0.71 | STIM1 (0.38) | SMN1; SMN2ALDH1A1GAAMAPTRAB9A | |
| SCHEMBL14887602 | 0.71 | STIM1 (0.37) | MAPK14ALDH1A1GAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | SMN1; SMN2 854/4885MAPK14 2933/4885ALDH1A1 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.