Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017301 | 0.94 | ALDH1A1 (0.43) | ALDH1A1HPGDMEN1KMT2AAPEX1 | |
| SCHEMBL14879558 | 0.86 | MPL (0.36) | ALDH1A1HPGDMEN1KMT2AAPEX1 | |
| SCHEMBL16017439 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HPGDAPEX1SMN1; SMN2STIM1 | |
| SCHEMBL16017303 | 0.82 | MEN1 (0.50) | ALDH1A1HPGDMEN1KMT2AAPEX1 | |
| SCHEMBL16017305 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HPGDAPEX1SMN1; SMN2GAA | |
| SCHEMBL14887607 | 0.81 | MEN1 (0.38) | ALDH1A1MEN1KMT2AAPEX1SMN1; SMN2 | |
| SCHEMBL16017299 | 0.80 | HPGD (0.44) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL14879431 | 0.80 | STIM1 (0.38) | ALDH1A1HPGDMEN1KMT2AAPEX1 | |
| SCHEMBL16017438 | 0.74 | MEN1 (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL16017437 | 0.72 | MEN1 (0.65) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ALDH1A1 4409/4885HPGD 1883/4885MEN1 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.