SCHEMBL16019261

SCHEMBL16019261

COc1cc2c(cc1OC)C1(CC2(C)C)CC(C)(C)c2cc3oc4cc5c(=O)n(-c6c(C)cc(-c7cc(C)c(N8C(=O)c9cc(C)c(C)cc9C8=O)c8ccccc78)c7ccccc67)c(=O)c5cc4oc3cc21

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.33
ALOX15 P16050 2/20 0.33
HTT P42858 2/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 4/20 0.33
LMNA P02545 2/20 0.33
KMT2A Q03164 4/20 0.32
MEN1 O00255 3/20 0.32
NPC1 O15118 2/20 0.32
MAOA P21397 3/20 0.32
RAB9A P51151 1/20 0.32
HPGD P15428 1/20 0.32
CASP1 P29466 1/20 0.32
GAA P10253 1/20 0.31
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16019264 0.89
SCHEMBL18327676 0.81
SCHEMBL16019262 0.78 ESR1 (0.32) HTTKMT2AMEN1
SCHEMBL13250931 0.76 KDM4E (0.39) KDM4ETSHRSMN1; SMN2ALDH1A1MAPT
SCHEMBL25513988 0.71 MEN1 (0.31) HTTALDH1A1MAPTLMNAKMT2A
SCHEMBL16019263 0.71 MAPT (0.30) HTTMAPTLMNA
SCHEMBL16019256 0.68 TDP1 (0.31)
SCHEMBL19075867 0.67
SCHEMBL24285571 0.64 LMNA (0.32) MAPTLMNA
SCHEMBL24285462 0.64 EGFR (0.35) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9522364-B2 Treated mixed matrix polymeric membranes SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-12-20 US disclosed
US-9492785-B2 UV and thermally treated polymeric membranes SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-11-15 US disclosed
US-20160263532-A1 ULTRAVIOLET AND PLASMA-TREATED POLYMERIC MEMBRANES SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-09-15 US disclosed
US-20160263531-A1 PLASMA-TREATED POLYMERIC MEMBRANES SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-09-15 US disclosed
US-20160263533-A1 TREATED MIXED MATRIX POLYMERIC MEMBRANES SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-09-15 US disclosed
US-20160250585-A1 UV AND THERMALLY TREATED POLYMERIC MEMBRANES SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-09-01 US disclosed
US-20140255636-A1 Polymeric Membranes SAUDI BASIC INDUSTRIES CORPORATION (SA) 2014-09-11 US disclosed