Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 9/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.48 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887328 | 0.86 | CRACR2A (0.60) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16017227 | 0.83 | KDM4E (0.44) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16019773 | 0.83 | GRM1 (0.48) | GRM1GRM4CRACR2ASTIM1ORAI1 | |
| SCHEMBL16019788 | 0.82 | DGAT1 (0.44) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL16017189 | 0.81 | STIM1 (0.51) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16019799 | 0.81 | STIM1 (0.43) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16017182 | 0.81 | BACE1 (0.44) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16017419 | 0.80 | ALDH1A1 (0.50) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16017183 | 0.80 | CRACR2A (0.55) | CRACR2ASTIM1ORAI1HDAC3HDAC4 | |
| SCHEMBL16008936 | 0.80 | STIM1 (0.52) | CRACR2ASTIM1ORAI1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | GRM1 1425/4885GRM4 1253/4885CRACR2A 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.