Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.41 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.41 |
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017238 | 0.85 | ATM (0.49) | CSNK1DCSNK1EATM | |
| SCHEMBL16020156 | 0.85 | ATR (0.47) | ATRNAMPTPIM2ATMSTIM1 | |
| SCHEMBL14887516 | 0.85 | NAMPT (0.51) | ATRNAMPTCSNK1DCSNK1EPIM2 | |
| SCHEMBL16019791 | 0.85 | ATR (0.49) | ATRNAMPTCSNK1DCSNK1EPIM2 | |
| SCHEMBL16017263 | 0.83 | ATM (0.47) | ATRATM | |
| SCHEMBL16017254 | 0.82 | LMNA (0.47) | ATMLMNA | |
| SCHEMBL14887595 | 0.81 | ATR (0.45) | ATRATMSTIM1ORAI1 | |
| SCHEMBL14887593 | 0.78 | ATR (0.43) | ATRATMSTIM1ORAI1LMNA | |
| SCHEMBL1134835 | 0.72 | ATM (0.61) | ATRNAMPTATMSSTR2NTRK1 | |
| SCHEMBL29445412 | 0.72 | ATM (0.61) | ATRNAMPTATMSSTR2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ATR 4430/4885NAMPT 2538/4885CSNK1D 1332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.