Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699068 | 0.91 | SCN9A (0.46) | SCN9AALDH1A1MAPTPOLBMCOLN3 | |
| SCHEMBL19627592 | 0.87 | SCN9A (0.43) | SCN9AMAPTPOLBGAACNR1 | |
| SCHEMBL9923641 | 0.84 | SCN9A (0.42) | SCN9A | |
| SCHEMBL15031959 | 0.82 | SCN9A (0.45) | SCN9AALDH1A1MAPTCNR1CNR2 | |
| SCHEMBL1109044 | 0.82 | SCN9A (0.47) | SCN9AALDH1A1MAPTPOLBGAA | |
| SCHEMBL16522683 | 0.81 | MAPT (0.38) | SCN9AALDH1A1MAPTPOLBNPSR1 | |
| SCHEMBL21810729 | 0.81 | LMNA (0.41) | SCN9AALDH1A1MAPTPOLBMCOLN3 | |
| SCHEMBL9923645 | 0.81 | SCN9A (0.38) | SCN9AALDH1A1LMNACNR1CNR2 | |
| SCHEMBL15202462 | 0.80 | SCN9A (0.53) | SCN9AALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL16109346 | 0.80 | SCN9A (0.48) | SCN9AALDH1A1MAPTPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346798-B2 | Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors | AMGEN INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-9079902-B2 | Heteroaryl sodium channel inhibitors | AMGEN INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20150057271-A1 | DIHYDROBENZOXAZINE AND TETRAHYDROQUINOXALINE SODIUM CHANNEL INHIBITORS | AMGEN INC. | 2015-02-26 | — | — | US | disclosed |
| US-20140256707-A1 | Heteroaryl Sodium Channel Inhibitors | AMGEN INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057271-A1 | DIHYDROBENZOXAZINE AND TETRAHYDROQUINOXALINE SODIUM CHANNEL INHIBITORS | SCN5A, KCNH1, KCNQ5 | SCN9A 83/4885ALDH1A1 1242/4885MAPT 3220/4885 |
| US-20140256707-A1 | Heteroaryl Sodium Channel Inhibitors | SCN1A, SCN5A, SCN1B | SCN9A 13/4885ALDH1A1 1377/4885MAPT 3233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.