Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23142766 | 0.95 | SLC18A3 (0.57) | HTTSMN1; SMN2L3MBTL1SLC18A3ESR2 | |
| SCHEMBL23142753 | 0.91 | SLC18A3 (0.53) | HTTSMN1; SMN2L3MBTL1SLC18A3ESR2 | |
| SCHEMBL5868999 | 0.88 | SLC18A3 (0.63) | HTTSMN1; SMN2L3MBTL1SLC18A3NAMPT | |
| SCHEMBL16022196 | 0.86 | SLC18A3 (0.62) | HTTSMN1; SMN2L3MBTL1SLC18A3NAMPT | |
| SCHEMBL15157030 | 0.82 | SLC18A3 (0.68) | HTTSMN1; SMN2L3MBTL1SLC18A3NAMPT | |
| SCHEMBL19647610 | 0.81 | ALDH1A1 (0.58) | HTTSMN1; SMN2L3MBTL1SLC18A3NAMPT | |
| SCHEMBL16704905 | 0.80 | HDAC3 (0.62) | SMN1; SMN2HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL16021444 | 0.80 | HDAC3 (0.62) | SMN1; SMN2HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL3822159 | 0.80 | SLC18A3 (0.67) | HTTSMN1; SMN2L3MBTL1SLC18A3NAMPT | |
| SCHEMBL11187396 | 0.79 | ESR2 (0.68) | ESR2CYP3A4MAPTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970326-B1 | SUBSTITUTED 5,6-RING-FUSED NAPHTHOPYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2017-11-29 | — | — | EP | disclosed |
| US-9029532-B2 | 5,6-ring-substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140256935-A1 | 5,6-RING-SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2014-09-11 | — | — | US | disclosed |