Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157030 | 0.98 | SLC18A3 (0.68) | SLC18A3HDAC8HDAC6HDAC3HDAC11 | |
| SCHEMBL16022196 | 0.95 | SLC18A3 (0.62) | SLC18A3HDAC8HDAC6HDAC3HDAC11 | |
| SCHEMBL5868999 | 0.91 | SLC18A3 (0.63) | SLC18A3HDAC8HDAC6HDAC3HDAC11 | |
| SCHEMBL11356835 | 0.85 | HDAC8 (0.64) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL23142766 | 0.84 | SLC18A3 (0.57) | SLC18A3HDAC8HDAC6HDAC3HDAC11 | |
| SCHEMBL11215485 | 0.84 | HDAC8 (0.62) | SLC18A3HDAC8HDAC6HDAC3HDAC11 | |
| SCHEMBL10127506 | 0.83 | NAMPT (0.59) | SLC18A3NAMPTCYP2C19HSD17B10 | |
| SCHEMBL23718998 | 0.83 | HDAC8 (0.57) | SLC18A3HDAC8HDAC6HDAC3HDAC11 | |
| SCHEMBL28263687 | 0.82 | — | — | |
| SCHEMBL7760744 | 0.82 | HDAC8 (0.60) | SLC18A3HDAC8HDAC6HDAC3HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969578-B2 | Inhibitors of STAT3 | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969578-B2 | Inhibitors of STAT3 | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-20110223661-A1 | INHIBITORS OF STAT3 | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110223661-A1 | INHIBITORS OF STAT3 | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, (US) | 2011-09-15 | — | — | US | disclosed |
| EP-1567477-B1 | SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | NOVARTIS AG (CH) | 2009-09-09 | — | — | EP | disclosed |
| EP-2090566-A2 | Certain phenylacetic acids and derivatives | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008099221-A1 | AMIDE AND UREA DERIVATIVES FOR THE TREATMENT OF METABOLIC DISEASES | PROSIDION LIMITED (GB) | 2008-08-21 | — | — | WO | disclosed |
| US-20070280957-A1 | Change of the Load State of Mhc Molecules | MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) | 2007-12-06 | — | — | US | disclosed |
| US-7202364-B2 | Certain phenylacetic acids and derivatives | NOVARTIS, AG (CH) | 2007-04-10 | — | — | US | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
| CN-1729157-A | Substituted amino phenylacetic acids, derivatives thereof, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors | NOVARTIS AG (CH) | 2006-02-01 | — | — | CN | disclosed |
| EP-1567477-A1 | SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | Novartis AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| US-20040132769-A1 | Certain phenylacetic acids and derivatives | NOVARTIS AG (CH) | 2004-07-08 | — | — | US | disclosed |
| WO-2004048314-A1 | SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | NOVARTIS AG (CH) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110223661-A1 | INHIBITORS OF STAT3 | STAT3, JAK2, STAT1 | SLC18A3 4880/4885HDAC8 545/4885HDAC6 70/4885 |
| US-20040132769-A1 | Certain phenylacetic acids and derivatives | CYP2A6, HCAR2, CYP2B6 | SLC18A3 3056/4885HDAC8 1105/4885HDAC6 1127/4885 |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | SLC18A3 4273/4885HDAC8 357/4885HDAC6 170/4885 |
| US-20070280957-A1 | Change of the Load State of Mhc Molecules | HLA-DRB1, MICA, CD74 | SLC18A3 814/4885HDAC8 2072/4885HDAC6 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.