SCHEMBL16022016

SCHEMBL16022016

Cn1nc(C(=O)O)c(=O)n(Cc2ccccc2)c1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
RAB9A P51151 1/20 0.48
HPGD P15428 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
ALDH1A1 P00352 2/20 0.47
POLB P06746 2/20 0.47
ADORA3 P0DMS8 1/20 0.46
ADORA2B P29275 1/20 0.46
CCNB2 O95067 1/20 0.45
CDK1 P06493 1/20 0.45
CCNB1 P14635 1/20 0.45
GSK3A P49840 1/20 0.45
GSK3B P49841 1/20 0.45
CCNB3 Q8WWL7 1/20 0.45
LMNA P02545 1/20 0.45
EEF2K O00418 1/20 0.45
NOTUM Q6P988 1/20 0.43
GAA P10253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17427368 0.90 SMN1; SMN2 (0.49) PKMSMN1; SMN2RAB9AHPGDMEN1
SCHEMBL17430001 0.84 MEN1 (0.52) SMN1; SMN2HPGDMEN1KMT2AALDH1A1
SCHEMBL15261897 0.82 EEF2K (0.54) HPGDKMT2AALDH1A1ADORA3LMNA
SCHEMBL7830937 0.78 ADORA3 (0.48) PKMSMN1; SMN2RAB9AHPGDMEN1
SCHEMBL16022014 0.78 POLB (0.51) PKMSMN1; SMN2RAB9AHPGDMEN1
SCHEMBL14969113 0.77 MAPK1 (0.40) PKMHPGDALDH1A1POLBADORA2B
SCHEMBL16034382 0.75 AXL (0.44) PKMMEN1KMT2AALDH1A1POLB
SCHEMBL17427488 0.75 MAPT (0.35) PKMRAB9AHPGDMEN1KMT2A
SCHEMBL14969121 0.75 AXL (0.44) SMN1; SMN2RAB9AHPGDMEN1KMT2A
SCHEMBL25275352 0.74 GSK3B (0.50) RAB9AHPGDMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160009693-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2016-01-14 US disclosed
US-20160009693-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2016-01-14 US disclosed
WO-2014135654-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2014-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160009693-A1 HERBICIDAL COMPOUNDS DDT, HAX1, CYP4X1 PKM 2217/4885SMN1; SMN2 4026/4885RAB9A 2062/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.