SCHEMBL160224

SCHEMBL160224

CCOP(=O)(OCC)C(F)(F)CCOCCOc1ccc(C=O)c(OC)c1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
MAOB P27338 2/20 0.41
CYP1A1 P04798 2/20 0.40
CYP1B1 Q16678 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
TUBB1 Q9H4B7 1/20 0.36
ROCK2 O75116 1/20 0.36
ROCK1 Q13464 1/20 0.36
ERN1 O75460 4/20 0.36
KDM4E B2RXH2 2/20 0.34
RECQL P46063 1/20 0.34
GCGR P47871 1/20 0.34
HDAC8 Q9BY41 1/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10277413 0.86 ALDH1A1 (0.47) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL10277355 0.84 CYP1A1 (0.39) CYP1A1CYP1B1KDM4EGCGRHDAC8
SCHEMBL10310982 0.81 ALDH1A1 (0.51) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL18045690 0.80 ALDH1A1 (0.67) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL267533 0.79 ALDH1A1 (0.49) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL5143351 0.75 ALDH1A1 (0.67) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL4059477 0.73 ALDH1A1 (0.67) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL20892596 0.73 ALDH1A1 (0.67) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL702232 0.72 ALDH1A1 (0.71) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1
SCHEMBL18068448 0.72 ALDH1A1 (0.54) ALDH1A1MAOBCYP1A1CYP1B1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2480253-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS Novartis AG (CH) 2012-08-01 EP disclosed
WO-2012031140-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS NOVARTIS AG (CH) 2012-03-08 WO disclosed