Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MAOB | P27338 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 3/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683800 | 0.97 | ALDH1A1 (0.63) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL14195830 | 0.95 | MAOB (0.62) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL4063273 | 0.95 | MAOB (0.62) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL20892596 | 0.94 | ALDH1A1 (0.67) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL4064858 | 0.90 | ALDH1A1 (0.51) | ALDH1A1MAOBL3MBTL1ERN1TDP1 | |
| SCHEMBL5654406 | 0.88 | ALDH1A1 (0.63) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL5654410 | 0.88 | ALDH1A1 (0.63) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL426335 | 0.88 | ALDH1A1 (0.63) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL13191485 | 0.87 | ALDH1A1 (0.67) | ALDH1A1MAOBL3MBTL1ERN1CYP1A1 | |
| SCHEMBL15728130 | 0.87 | TUBB1 (0.61) | ALDH1A1MAOBERN1TUBB1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855419-B1 | NEW INDANYLOXYPHENYLCYCLOPROPANECARB OXYLIC ACIDS | BOEHRINGER INGELHEIM INT (DE) | 2017-03-01 | — | — | EP | disclosed |
| US-9278915-B2 | Agonists of GPR40 | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2016-03-08 | — | — | US | disclosed |
| US-8633182-B2 | Indanyloxyphenylcyclopropanecarboxylic acids | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-21 | — | — | US | disclosed |
| WO-2013178575-A1 | NEW INDANYLOXYPHENYLCYCLOPROPANECARB OXYLIC ACIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-12-05 | — | — | WO | disclosed |
| US-20130237571-A1 | AGONISTS OF GPR40 | Conexios Life Sciences PVT. LTD. (IN) | 2013-09-12 | — | — | US | disclosed |
| WO-2010111353-A1 | N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS | ACADIA PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| CN-100577651-C | Lactam compound and medicinal use thereof | AJINOMOTO KK | 2010-01-06 | — | — | CN | disclosed |
| US-7632830-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2009-12-15 | — | — | US | disclosed |
| EP-1346993-B1 | LACTAM COMPOUNDS AND MEDICAL USE THEREOF | AJINOMOTO KK (JP) | 2009-10-21 | — | — | EP | disclosed |
| US-20080096862-A1 | LACTAM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | AJINOMOTO CO., INC. (JP) | 2008-04-24 | — | — | US | disclosed |
| US-7326701-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2008-02-05 | — | — | US | disclosed |
| CN-1911915-A | Lactam compound and medicinal use thereof | AJINOMOTO KK (JP) | 2007-02-14 | — | — | CN | disclosed |
| US-7153850-B2 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20060189597-A1 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-08-24 | — | — | US | disclosed |
| CN-1269818-C | Lactam compounds and pharmaceutical use thereof | AJINOMOTO KK (JP) | 2006-08-16 | — | — | CN | disclosed |
| CN-1487940-A | Lactam compounds and pharmaceutical use thereof | ֮����ʽ���� | 2004-04-07 | — | — | CN | disclosed |
| US-20040048847-A1 | Lactam compounds and pharmaceutical use thereof | AJINOMOTO CO. INC (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1346993-A1 | LACTAM COMPOUNDS AND MEDICINAL USE THEREOF | Ajinomoto Co., Inc. (JP) | 2003-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189597-A1 | Lactam compounds and pharmaceutical use thereof | SLC2A4, SLC2A8, SLC2A1 | ALDH1A1 911/4885MAOB 2230/4885L3MBTL1 4773/4885 |
| US-20130237571-A1 | AGONISTS OF GPR40 | GPR65, GPR55, GPR68 | ALDH1A1 2410/4885MAOB 2832/4885L3MBTL1 4507/4885 |
| US-20040048847-A1 | Lactam compounds and pharmaceutical use thereof | SLC2A4, SLC2A8, SLC2A1 | ALDH1A1 911/4885MAOB 2230/4885L3MBTL1 4773/4885 |
| US-20080096862-A1 | LACTAM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | SLC2A4, SLC2A8, SLC2A1 | ALDH1A1 911/4885MAOB 2230/4885L3MBTL1 4773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.