Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 20/20 | 0.88 |
| ▸ | SIRT1 | Q96EB6 | 20/20 | 0.88 |
| ▸ | SIRT3 | Q9NTG7 | 20/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17389390 | 0.94 | SIRT2 (0.78) | SIRT2SIRT1SIRT3CYP2C9 | |
| SCHEMBL16011506 | 0.93 | SIRT2 (1.00) | SIRT2SIRT1SIRT3CYP2C9 | |
| Hydrochloric Acid SCHEMBL17389379 | 0.92 | SIRT2 (0.98) | SIRT2SIRT1SIRT3CYP2C9 | |
| SCHEMBL17400947 | 0.90 | SIRT2 (0.72) | SIRT2SIRT1SIRT3CYP2C9 | |
| SCHEMBL16023422 | 0.89 | SIRT2 (0.83) | SIRT2SIRT1SIRT3CYP2C9 | |
| SCHEMBL16011520 | 0.89 | SIRT2 (0.83) | SIRT2SIRT1SIRT3CYP2C9 | |
| Hydrochloric Acid SCHEMBL17389383 | 0.88 | SIRT2 (0.81) | SIRT2SIRT1SIRT3CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL16014052 | 0.88 | SIRT2 (0.88) | SIRT2SIRT1SIRT3CYP2C9 | |
| SCHEMBL17389387 | 0.87 | SIRT2 (0.82) | SIRT2SIRT1SIRT3CYP2C9 | |
| SCHEMBL16023507 | 0.86 | SIRT2 (0.79) | SIRT2SIRT1SIRT3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160002273-A1 | THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-01-07 | — | — | US | disclosed |
| US-20160002273-A1 | THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-01-07 | — | — | US | disclosed |
| WO-2014138562-A1 | THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002273-A1 | THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS | SIRT2, SIRT1, SIRT6 | SIRT2 1/4885SIRT1 2/4885SIRT3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.