Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048728 | 0.88 | LMNA (0.39) | LMNAHTT | |
| SCHEMBL19513492 | 0.81 | LMNA (0.38) | TSHRLMNAHTTCYP3A4MAPK1 | |
| SCHEMBL14074306 | 0.78 | — | — | |
| SCHEMBL23898990 | 0.75 | LMNA (0.47) | LMNAHTTCYP3A4 | |
| SCHEMBL12722836 | 0.73 | GSK3B (0.35) | TSHRLMNAHTTCYP3A4 | |
| SCHEMBL27874098 | 0.71 | NPC1 (0.38) | LMNAHTTMAPK1 | |
| SCHEMBL1135594 | 0.71 | TSHR (0.44) | TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL29637482 | 0.71 | TSHR (0.44) | TSHRLMNACYP3A4MAPK1 | |
| SCHEMBL3279189 | 0.70 | MAPT (0.39) | LMNAHTTCYP3A4MAPK1 | |
| SCHEMBL18975227 | 0.69 | LMNA (0.33) | TSHRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014137719-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2014-09-12 | — | — | WO | disclosed |