Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.59 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16014217 | 0.81 | IDO1 (0.58) | ITKLRRK2MAPK1MKNK1TTK | |
| SCHEMBL16025492 | 0.78 | LRRK2 (0.72) | NTRK1LRRK2 | |
| SCHEMBL6949849 | 0.76 | LOXL2 (0.57) | CYP3A4 | |
| SCHEMBL16025587 | 0.76 | MAPK1 (0.51) | NTRK1LRRK2MAPK1MKNK1DYRK1A | |
| SCHEMBL16025493 | 0.76 | FLT3 (0.62) | NTRK1ITKLRRK2MAPK1MKNK1 | |
| SCHEMBL2473158 | 0.76 | AXL (0.52) | NTRK1LRRK2MAPK1MKNK1CLK2 | |
| SCHEMBL16025826 | 0.76 | MAP2K4 (0.63) | NTRK1ITKLRRK2MAPK1MAP2K4 | |
| SCHEMBL3512392 | 0.75 | JAK2 (0.58) | NTRK1MAPK1DCLK1PRKD3MAP4K4 | |
| SCHEMBL16025573 | 0.75 | TTK (0.48) | NTRK1LRRK2MAPK1MKNK1TTK | |
| SCHEMBL5379787 | 0.74 | NTRK1 (0.56) | NTRK1ITKMAPK1MKNK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964221-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | disclosed |
| WO-2014137728-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2014-09-12 | — | — | WO | disclosed |